Osteoarthritis (OA) is defined as the clinical and pathological outcome of a range of disorders that result in structural and functional failure of synovial joints 1 and is associated with progressive and irreversible destruction of articular cartilage that leads to chronic pain, joint instability, swelling, stiffness, and radiographic joint space narrowing 2
Jointechlabs miniTC cell viability and content validation study
Regenerative cells found in human fat are a mixed population of stromal and vascular cells found around blood vessels and between adipocytes in the matrix of fat. Most of these cells are covalently bound to small blood vessels in the matrices of fat which surround adipocytes. By definition, Stromal Vascular Fraction (SVF) is composed of stromal and vascular cells. A small proportion of the stromal cells are stem cells, which have been shown to be capable of differentiating into different structures (pluripotency).
We describe a case report of a patient who had presented with chronic right Achilles Tendon pain and weakness. An MRI of the right Achilles tendon without contrast
revealed significant expansion of the Achilles tendon in the traverse and anteroposterior dimension with extensive increased T2 signal consistent with large partial thickness Achilles tendon tear. A musculoskeletal ultrasound using a Sonosite X-Porte linear transducer demonstrated an anechoic tendon defect measuring 0.97cm in the longitudinal axis with a total tendon length measuring 1.53cm, as well as a 0.9cm defect in the transverse axis surrounded by homogenous tendon fibers consistent with a large defect involving the distal Achilles tendon proximal to the distal insertion.
To address the current deficit of sustainable lymphedema treatment, we investigated lymphatic regeneration guided by thread-like aligned nanofibrillar collagen scaffolds (BioBridge), which facilitate cell attachment, alignment, and migration. In this study, we tested our hypothesis that implantation of BioBridge with seeded Mini-Stem System harvested Adipose-Derived Stem Cells (ADSCs) can reduce lymphedema when used in animals with developed lymphedema.
Statement of Purpose: Chronic skin wounds such as diabetic ulcers and pressure ulcers have high prevalence in patients with poor circulation, neuropathy, and infection. 1 A regenerative approach using a combination of adipose stem cells (ASCs) and fat-derived stromal vascular fraction (SVF) can be an effective strategy for healing of chronic wounds via regulation of growth factors and cytokines, targeted cell response, and new blood vessel formation
